IRAK4 Activation: A Cautious Embrace
نویسندگان
چکیده
منابع مشابه
Cautious apoptosis
In This Issue In This Issue Held back by a finger he familiar arm-over-arm kinesin swing was recently challenged by proposals that KIF1A acts as a processive, but monomeric, kinesin motor. The proposal involved a rotation of the motor that, along with a microtubule-binding patch, would bias further movement in one direction. But now Al-Bassam et al. add to the growing evidence that the KIF1A or...
متن کاملCautious Classifiers
The evaluation and use of classifiers is based on the idea that a classifier is defined as a complete function from instances to classes. Even when probabilistic classifiers are used, these are ultimately converted into categorical classifiers that must choose one class (with more or less confidence) from a set of classes. Evaluation metrics such as accuracy/error, global cost, precision, recal...
متن کاملEMBRACE System Demonstrator
Within the EMBRACE project an advanced communications system and network was developed. It uses the DVB technology for the high-speed downlink and a novel multi-frequency TDMA system for the return link. The return link is scaleable to accommodate the variety of data rates. Emphasis was put on providing quality of service (QoS) in wireless IP networks. Site diversity is used to increase the ava...
متن کاملThe EMBRACE System Demonstrator
Within the EMBRACE project an advanced communications system and network was developed. It uses the DVB technology for the high-speed downlink and a novel multi-frequency TDMA system for the return link. The return link is scaleable to accommodate the variety of data rates. Emphasis was put on providing quality of service (QoS) in wireless IP networks. Site diversity is used to increase the ava...
متن کاملThe mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists
We have developed the first assays that measure the protein kinase activities of interleukin-1 receptor-associated kinase 1 (IRAK1) and IRAK4 reliably in human cell extracts, by employing Pellino1 as a substrate in conjunction with specific pharmacological inhibitors of IRAK1 and IRAK4. We exploited these assays to show that IRAK4 was constitutively active and that its intrinsic activity toward...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2014
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2014.09.003